By Robert G. Forman, Susanna K. Gilmour-White, Nathalie H. Forman
This particular resource of reference presents a finished advisor to the antagonistic side-effects of many as a rule prescription drugs on fertility and sexual overall healthiness. greater than one hundred fifty medicinal drugs are indexed during this compilation, and the facts linking them with infertility and sexual disorder is punctiliously reviewed. the quantity is designed to supply a speedy resource of connection with alert medical professionals and pharmacists to those detrimental side-effects. the quantity additionally contains an introductory account of the reproductive approach and a assessment of the mechanisms in which those medicinal drugs can intrude or inhibit copy. one other vital topic of the amount is the influence of social and leisure medicinal drugs and environmental brokers on reproductive health and wellbeing.
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Additional resources for Drug-Induced Infertility and Sexual Dysfunction
Inhibited ejaculation was described in three patients at unknown doses (Mitchell and Popkin, 1983). Tetracydie antidepressants Maprotiline. Maprotiline is a tetracyclic antidepressant with similar anticholinergic effects to tricyclic compounds. Decreased libido, impotence and erectile failure were described in case reports. Mianserin. Mianserin is a tetracyclic antidepressant with antiserotonergic properties. , 1985). Non-tricyclic antidepressants Trazodone This drug is a triazolopyridine antidepressant.
Since then numerous case reports and a few studies describe decreased libido, difficulty achieving and maintaining erections and inability to achieve orgasm. The drug has even been used therapeutically in an attempt to treat hypersexuality and premature ejaculation (Mitchell and Popkin, 1982). Kotin and colleagues performed a large study investigating thioridazineinduced sexual dysfunction in sexually active schizophrenics (Kotin et al, 1976). Thioridazine produced some form of sexual dysfunction in 60% of patients; 44% of thioridazine-treated patients developed difficulties achieving erection compared with 19% in patients treated with other major tranquilisers.
As described previously, propranolol-induced impotence has been reversed by changing therapy to atenolol. 24 Antihypertensive therapy Metoprolol The same considerations apply to metoprolol as atenolol, as this drug is also cardiospecific. Isolated reports of disturbances of libido and potency are mentioned in the data sheet supplied by the manufacturers. There were no reports of sexual problems in one study of over 10 000 hypertensive patients treated with metoprolol (Buffum, 1982). Atenolol and, to a lesser extent, metoprolol have reduced lipid solubility compared with propranolol.