By John A. Adamovics
Up to date and revised all through. moment version explores the chromatographic equipment used for the size of gear, impurities, and excipients in pharmaceutical preparations--such as capsules, ointments, and injectables. includes a 148-page desk directory the chromatographic facts of over 1300 medicinal drugs and similar substances--including pattern matrix analyzed, pattern dealing with methods, column packings, cellular section, mode of detection, and extra.
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Additional info for Chromatographic Analysis of Pharmaceuticals
For TLC, silica gel is by far the most widely used sorbent, and glass is the most popular sorbent support. Adherence to the glass plate is generally accomplished by the addition of such binding agents such as calcium sul fate. 1 . Most of these sorbents are carefully controlled in terms of consis- I tent pore size, particle size, and surface area. A number of chromatographic procedures, particularily the separations that use anhydrous devel oping solvents, require control of the silica gel moisture content.
4. Specific detectors are also available for quantification of radiophar maceuticals. These detectors use a position-sensitive proportional counter. 5. The detector analog output can also be represented as an analog curve. Various other detection procedures have also been used, such as flame ionization , mass spectrometry [27,67], and infrared (IR) [68,69]. IV. METHODSDEVELOPMENT Planar techniques can tolerate application of either solutions or suspen sions. In addition, the solvent used to dissolve the sample need not be compatible with the TLC mobile phase as is the case for HPLC methods.
These phases are stable to about 3000C. 82 Adamovics and Eschbach C. Liquid-Crystal Phases Liquid-crystalline stationary-phase selectivity is thought to occur through the geometrical interaction of the ordered crystals which are coupled to the polysiloxane backbone, with the geometrical features of the solute. Reten tion on these phases is highly dependent on the solute size, shape, and how well it fits into the uniform arrangements of the stationary phase. The degree of order associated with each crystalline phase varies with the tem perature.